克罗米酚对男性低促性腺素性功能减退症有效性

纽约（保险业社健康版）1年初四日报道：据撰写在12年初出版的《不育与不育》杂志的一项报告指出克罗米酮对部分较高促特质腺效特质功能有所增加的成人病变险恶。来自伯明翰阿拉巴马该大学的该报告的第一笔记Scott J. WhittenDr在放弃保险业通讯社采访时说：“病症或获得特质HH病变在放弃损害特质更大和更为昂贵的放射治疗（例如注射促特质腺激效类）前同步进行4个年初的克罗米酮实验特质放射治疗是险恶的。”WhittenDr和上司研究了克罗米酮对10名HH成人病变（HH是导致成人不育的有名因效）是否有效。报告称克罗米酮放射治疗1年后，4名卡尔曼(氏)综合征病变中只有一名病变的卵子浓度增加而全垂体功能有所增加症病变的卵子缺失症状均没有得到改善。只不过，该报告指出3名成年发病的病症HH成人病变经过3个年初克罗米酮的放射治疗卵子浓度有了明显增加。目前为止该组病变已有两名维持了不育能力。WhittenDr说：“除非对克罗米酮放射治疗没有加成，我们不会因为副作用中止对病变应用于该药品。”最后笔记归纳说：“因为条件有限，对HH病变促特质腺激效类药品和克罗米酮的随机研究难于同步进行，然而利用多系列的恰当选择标准对病变同步进行分级可能帮助必要特质验证克罗米酮维持成人较高不育能力的有效特质。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

总编：金色幻想

总编： 张靖